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WuXi AppTecMilestone

Breaking the Stapled Peptide Bottleneck: WuXi AppTec's WuXi TIDES Delivers Kilogram-Scale GMP API in 8 Months

A Phase 2 triple stapled peptide project that stalled at another CDMO was transferred to WuXi AppTec. Through integrated WuXi TIDES execution — in-house UAA supply in 6 weeks, re-engineered RCM lifting crude purity 33%, and a metal-scavenging step cutting residual ruthenium ~75-fold — kilogram-scale GMP API was delivered in 8 months and Phase 2 CTM released in 11.